24
- febbraio
2021
Posted By : allenamente_adm1n
No Comments
Study protocol: improving cognition in people with progressive multiple sclerosis: a multi-arm, randomized, blinded, shamcontrolled trial of cognitive rehabilitation and aerobic exercise (COGEx)

Abstract
Background: Cognitive dysfunction affects up to 70% of people with progressive MS (PMS). It can exert a
deleterious effect on activities of daily living, employment and relationships. Preliminary evidence suggests that
performance can improve with cognitive rehabilitation (CR) and aerobic exercise (EX), but existing data are
predominantly from people with relapsing-remitting MS without cognitive impairment. There is therefore a need to
investigate whether this is also the case in people with progressive forms of the disease who have objectively
identified cognitive impairment. It is hypothesized that CR and EX are effective treatments for people with PMS
who have cognitive impairment, in particular processing speed (PS) deficits, and that a combination of these two
treatments is more effective than each individual treatment given alone. We further hypothesize that improvements
in PS will be associated with modifications of functional and/or structural plasticity within specific brain networks/
regions involved in PS measured with advanced MRI techniques.

sclerosi

Category: